Syntheses of 11-substituted 3-methyl-3,4,10,11-tetrahydro-1H,5H-pyrano(4,3-b)(1,5)benzodiazepin-1-ones.
نویسندگان
چکیده
منابع مشابه
Syntheses of 11-substituted 3-methyl-3,4,10,11-tetrahydro-1H,5H-pyrano[4, 3-b][1,5]benzodiazepin-1-ones.
In the course of our synthetic studies on biologically active compounds using dimedone, tetronic acids, and tetramic acids,1) we reported that some 10-substituted 3,3-dimethyl3, 4, 9, 10tetrahydro1Hfuroand -pyrrolo [4, 3-b] [1, 5] benzodiazepin1-ones (1 and 2) showed analgesic activity as strong as that of aminopyrine in the phenylquinone writhing test in mice.2) Namely, the extents of inhibiti...
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The reaction of P-diketones 1 with phenyl hydrazine afforded 5-aryl-3-(1- methyl-5-nitro-2-imidazoly1)-1-phenylpyrazole (2) and 3-aryl-5-(1-methyl-5- nitro-2-imidazoly1) -1-phenylpyrazole (3). The reaction of diketones (1) with urea in the presence of p-toluenesulfonic acid gave 4-(or 6-)aryl-6-(or 4-)(1-methyl- 5-nitro-2-imidazolyl)-1-(lH)pyrimidones (4). The structures of all compounds w...
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The syntheses of the title compounds are described. 1- [[2- Amino -1 - (hydroxymethyl) ethoxy] methyl] uracil exhibitslittleactivity against herpesviruses (HSV) in vivo
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In the title compound, C(10)H(12)N(2)S, the thio-phene ring is essentially planar (r.m.s. deviation = 0.0290 Å). The two C atoms of the cyclo-hexene ring (at positions 6 and 7) are disordered over two sets of sites in a 0.810 (5):0.190 (5) ratio. The cyclo-hexene rings in both the major and minor occupancy conformers adopt a half-chair conformation. In the crystal, there are two types of N-H⋯N ...
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the reaction of p-diketones 1 with phenyl hydrazine afforded 5-aryl-3-(1- methyl-5-nitro-2-imidazoly1)-1-phenylpyrazole (2) and 3-aryl-5-(1-methyl-5- nitro-2-imidazoly1) -1-phenylpyrazole (3). the reaction of diketones (1) with urea in the presence of p-toluenesulfonic acid gave 4-(or 6-)aryl-6-(or 4-)(1-methyl- 5-nitro-2-imidazolyl)-1-(lh)pyrimidones (4). the structures of all compounds were c...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1987
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.35.5024